The story centers on a religiously conservative, married southern woman who receives a message from God instructing her to act as a surrogate mother and carry a child for two married gay men who live in Boston - a Jewish doctor and and African-American dance choreographer. All Hell breaks loose when the African American man comes to her home down south to micro-manage her pregnancy, and he won't leave.

A simple man, Dr. Walter Newman, has high aspirations to cure all disease through genetic manipulation. His obsession with his mission draws him deeper into his own dark world, distracting him from his wife Olivia and from his responsibilities to his patients at the Edgewood Asylum. The doctors loyal but diabolical nurse, Ms. Tinsley, decides to take matters into her own hands and in secret she conducts her own experiment. When Dr. Newman realizes what has been done, a deformed creature that defies nature is created. Part human, part nightmare. Dr. Newman knows what he must do, but is it already too late?